Our research investigates the role of macrophages in human health and disease. Macrophages are the most abundant immune cells resident at interfaces with the microbiota. We investigate the development, activation and microenvironmental programming of macrophages and the impact on tissue homeostasis, mucosal control of bacteria and pathogenesis of streptococcal, staphylococcal and mycobacterial infections.
- Clinical studies
- Infection models in vitro and in mice (including fate mapping)
- High resolution and time lapse microscopy
- Flow cytometry of rare tissue cell subsets