Dr. Senthilkumar Ramamoorthy and PD Dr. Brigitte Strahm, Division of Pediatric Hematology and Oncology, received a grant from the Deutsche José Carreras Leukämie Stiftung (DJCLS) for their project entitled „Role of genetic and epigenetic factors and associated non-coding functional elements in thedevelopment of therapy related myelodysplastic syndrome in children“.
Therapy-related myelodysplastic syndrome (tMDS) developing in children following treatment of primary cancers is among the most devastating long-term sequelae of these therapies. The overarching aim of the proposed study is to provide a comprehensive genome-wide mechanistic overview of the therapy-induced changes that lead to tMDS in children with various primary malignancies. Integrative analysis of the genomic, epigenomic, and transcriptomic profiles of pediatric patients with secondary MDS will not only advance our understanding but also lead to the identification of early biomarkers indicative of disease progression and novel therapeutic targets.
Congratulations, Dr. Ramamoorthy and Dr. Strahm!