Baasch et al., Cell (2021), https://doi.org/10.1016/j.cell.2021.05.00
Co-evolution of CMVs and their hosts has led to exploitation of the first line of defense and conserved signaling pathways. Upon infection, macrophages are targeted primarily by MCMV and reprogrammed via activation of Wnt and TGF-b. This cell state serves viral replication and dissemination at the expense of cell-intrinsic traits.
This research has been selected for presentation as a talk at the following recent and upcoming conferences:
- 05/2021 Novel Concepts in Innate Immunity [digital]
- 06/2021 34th Annual Conference of the European Macrophage and Dendritic Cell Society [digital]
- 09/2021 6th European Congress of Immunology [digital]