Embryonic Stem Cells
Embryonic stem (ES) cells are pluripotent and have the capacity to differentiate into any cell type of the body. Thus, ES cells are powerful tools to better understand the development of cells and organs, and for potential future therapeutic applications. In the Kirak lab, we are mainly interested in the development of fully functional pancreatic beta-cells and their interaction with immune cells.
Somatic Cell Nuclear Transfer
Somatic Cell Nuclear Transfer (SCNT or NT) is a powerful tool to epigenetically reprogram somatic cells. Dr. Kirak has pioneered the use of SCNT to develop novel T and B cell mouse models that express their antigen receptors from their physiological TCR and BCR regions, respectively.